Open drug discovery of anti-virals critical for Canada’s pandemic strategy
نویسندگان
چکیده
منابع مشابه
A strategy for drug discovery
Acid fuels the motion of a threaded ring A central goal in the construction of molecular-scale machines is the efficient achievement of oneway motion. Erbas-Cakmak et al. developed a class of machines that transmit pH changes into the two-stage guided motion of molecular rings threaded on a linear or cyclic axle. The design relies on temporary blocking groups and landing sites along the axle th...
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The Zika virus (ZIKV) outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting points for drug discovery. Our response can build on previous efforts with virus outbreaks and lean heavily on work done on other flaviviruses such...
متن کاملOpen PHACTS: semantic interoperability for drug discovery.
Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery r...
متن کاملToward the Development of a Single-Round Infection Assay Based on EGFP Reporting for Anti-HIV-1 Drug Discovery
Background: The rapid increase of HIV-1 strains resistant to current antiretroviral drugs is a challenge for successful AIDS therapy. This necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. Herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...
متن کاملOpen Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field
BACKGROUND There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. RESULTS The Open Drug Discovery To...
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ژورنال
عنوان ژورنال: FACETS
سال: 2020
ISSN: 2371-1671
DOI: 10.1139/facets-2020-0079